Thermo Fisher Scientific Granzyme K Monoclonal Antibody (GM24C3)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1.2 µg/1×10^6 cells

ELISA (ELISA)

• Tested Dilution: 1:200–1:400

Product Specifications

Product Specific Information

This antibody recognizes native Granzyme K protein expressed in transfected mammalian cells.

Target Information

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localized in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11–12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specificity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen, and peripheral blood leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.