Thermo Fisher Scientific Granzyme K Monoclonal Antibody (GM24C3)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1.2 µg/1x10^6 cells

-

ELISA (ELISA)

1:200-1:400

-

Product Specifications

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

GM24C3

Immunogen

cDNA encoding human Granzyme K

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2247979

Product Specific Information

This antibody recognizes native Granzyme K protein expressed in transfected mammalian cells.

Target Information

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.