Thermo Fisher Scientific GLRA1 Polyclonal Antibody
GLRA1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. Human 및 Rat에 반응하며 항원 친화 크로마토그래피로 정제. 4°C 단기, -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 35–256 of Human Glycine Receptor alpha1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2545838 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Raji
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (95%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GLRA1 is a subunit of a pentameric inhibitory glycine receptor that mediates postsynaptic inhibition in the central nervous system.
Defects in GLRA1 are associated with startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.
Multiple transcript variants encoding different isoforms have been identified.
Glycine receptors (GlyR) containing GLRA1 belong to the cys-loop family of ligand-gated ion channels, mediating inhibitory effects of glycine.
GLRA1 is widely distributed throughout the CNS, particularly within the hippocampus, spinal cord, and brain stem.
Diseases associated with GLRA1 include Hereditary Hyperekplexia 1.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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