Thermo Fisher Scientific GEF-H1 Monoclonal Antibody (GT1132)
GEF-H1 단백질을 인식하는 mouse monoclonal 항체로, WB 및 IHC(P) 실험에 적합. Human, Mouse, Rat에 반응하며 Protein G로 정제된 액상 형태. 세포 이동성과 Rho GTPase 관련 연구에 유용. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT1132 |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human GEF-H1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C short term; for long term, store at −20 °C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735200 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, Neuro2A, GL261, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat-2, 3A6
- Predicted Reactivity: Dog (92%), Pig (96%), Bovine (94%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GEF-H1 activates Rho GTPases by promoting the exchange of GDP and GTP.
Rho GTPases are involved in numerous cellular processes initiated by extracellular stimuli acting through G protein-coupled receptors.
GEF-H1 may play roles in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer.
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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