Thermo Fisher Scientific Iscalimab Humanized Recombinant Human Monoclonal Antibody
인간 CD40을 표적으로 하는 인간화 재조합 단클론 항체로, CD40-CD154 경로 억제 연구에 적합합니다. ELISA에 최적화되어 있으며, 높은 순도와 낮은 엔도톡신 수준을 제공합니다. 단백질 A로 정제된 액상 형태로, 연구용으로만 사용 가능합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | Human CD40 / TNFRSF5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.24 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.5 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911330 |
Product Specific Information
- Endotoxin level: < 0.01 EU/µg by LAL method
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Store at 2–8°C for one week.
- Store at -20 to -80°C for up to twelve months from the date of receipt.
Target Information
Iscalimab (CFZ533) is a fully humanized monoclonal antibody targeting CD40, a key molecule in the CD40–CD154 costimulatory pathway. By blocking this pathway, Iscalimab can inhibit CD40 signal transduction and CD40⁺ cell activation. It is under investigation as a potential therapeutic for solid organ transplantation and autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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