Thermo Fisher Scientific ECSIT Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ECSIT.

Target Information

Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88 to kinases like IRAK and intermediates such as TRAF6.
ECSIT (Evolutionarily Conserved Signaling Intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TRAF6 in the TLR pathway.
Recently, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, suggesting possible cross-talk between TLR/IL-B and Bmp signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.