Thermo Fisher Scientific COL4A5 Polyclonal Antibody
COL4A5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 사용 가능. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도, PBS/glycerol 저장. 인간 시료 반응성, basement membrane 연구에 적합.
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Thermo Fisher Scientific COL4A5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1462–1691 of human COL4A5 (NP_203699.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914811 |
Product Specific Information
Positive test controls include: 22Rv1, NCI-H460, HepG2.
The target is usually found in the following locations: Secreted, basement membrane, extracellular matrix, extracellular space.
Immunogen sequence:
SSVAHGFLIT RHSQTTDAPQ CPQGTLQVYE GFSLLYVQGN KRAHGQDLGT AGSCLRRFST MPFMFCNINN VCNFASRNDY SYWLSTPEPM PMSMQPLKGQ SIQPFISRCA VCEAPAVVIA VHSQTIQIPH CPQGWDSLWI GYSFMMHTSA GAEGSGQALA SPGSCLEEFR SAPFIECHGR GTCNYYANSY SFWLATVDVS DMFSKPQSET LKAGDLRTRI SRCQVCMKRT
Target Information
Collagens are highly conserved and characterized by an uninterrupted Glycine-X-Y triplet repeat.
- Col1: Found in most connective tissues; mutations cause osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis.
- Col2: Found in cartilage and vitreous humor; mutations associated with achondrogenesis, chondrodysplasia, familial osteoarthritis, SED congenita, Kniest dysplasia.
- Col3: Found in extensible connective tissues (skin, lung, vascular system); mutations linked to Ehlers-Danlos syndrome type IV and arterial aneurysms.
- Col4: Major constituent of basement membranes; composed of alpha 1 IV and alpha 2 IV chains in 2:1 ratio. Useful for detecting basement membrane loss in carcinomas.
- Col5: Regulates assembly of fibers composed of Col1 and Col5; mutations associated with Ehlers-Danlos syndrome.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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