Thermo Fisher Scientific CDK4 Antibody Cocktail
CDK4 단백질을 표적하는 마우스 IgG1 항체 칵테일로, WB, IP, IF 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 0.2 mg/mL 농도의 액상 형태로 제공됩니다. 세포 증식 조절 연구에 활용됩니다.
- 카탈로그번호
- MA513720
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CDK4 Antibody Cocktail
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 12 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View publications |
| Immunoprecipitation (IP) | 2 µg/mL | View 4 publications |
Product Specifications
| Property | Description |
|---|---|
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Cocktail |
| Type | Antibody |
| Clone | DCS-31, DCS-35 |
| Immunogen | Purified recombinant CDK4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981137 |
Product Specific Information
MA5-13720 targets CDK4 in IF, IP, and WB applications and shows reactivity with human, mouse, and rat samples.
The MA5-13720 immunogen is purified recombinant CDK4 protein.
Target Information
CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of the cell cycle.
CDK4 forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2).
CDK4 mediates phosphorylation of the C-terminal region of the Rb protein, leading to transcriptional repression of the E2F complex.
CDC37 and HSP90 preferentially associate with CDK4 not bound to D-type cyclins.
SMAD3 is a major physiologic substrate of CDK4 and CDK2.
Although CDK6 and CDK4 both phosphorylate multiple residues in the Rb protein, they show different residue selectivity in vitro: CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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