Thermo Fisher Scientific CDK4 Antibody Cocktail

Thermo Fisher Scientific CDK4 Antibody Cocktail

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-13720 targets CDK4 in IF, IP, and WB applications and shows reactivity with human, mouse, and rat samples.
The MA5-13720 immunogen is purified recombinant CDK4 protein.

Target Information

CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of the cell cycle.
CDK4 forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2).
CDK4 mediates phosphorylation of the C-terminal region of the Rb protein, leading to transcriptional repression of the E2F complex.
CDC37 and HSP90 preferentially associate with CDK4 not bound to D-type cyclins.
SMAD3 is a major physiologic substrate of CDK4 and CDK2.
Although CDK6 and CDK4 both phosphorylate multiple residues in the Rb protein, they show different residue selectivity in vitro: CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.