Thermo Fisher Scientific LILRB3 Recombinant Rabbit Monoclonal Antibody (058)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody has specificity for Mouse LILRB3.

Target Information

The LILRB3 gene belongs to the leukocyte immunoglobulin-like receptor (LIR) family, located at chromosomal region 19q13.4. The encoded protein is a subfamily B class receptor containing two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

This receptor is expressed on immune cells, binds to MHC class I molecules on antigen-presenting cells, and transduces a negative signal that inhibits immune stimulation. It helps regulate inflammatory responses and cytotoxicity, focusing the immune response and limiting autoreactivity. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.