Thermo Fisher Scientific BCL6 Monoclonal Antibody (PCRP-BCL6-1E2)
BCL6 단클론 항체(PCRP-BCL6-1E2)는 인간 BCL6 단백질을 인식하는 Mouse IgG2b 항체로, ICC/IF, Flow Cytometry, Peptide Array에 사용 가능. DLBCL 등 림프종 연구용으로 적합하며, 핵 및 미토콘드리아 위치 검출에 활용. 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-BCL6-1E2 |
| Immunogen | Recombinant full-length human BCL6 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: HeLa or MCF-7 cells
- Cellular Localization: Nucleus, Mitochondria
- Specificity Comments:
Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, Bcl-6, and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes.
Bcl-6 helps distinguish classical Hodgkin lymphoma (Bcl-6 negative) from nodular lymphocyte predominant Hodgkin lymphoma (Bcl-6 positive).
Anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Target Information
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas.
Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin’s lymphomas, detected in 33–45% of diffuse large B-cell lymphomas.
Immunohistochemical detection includes follicular lymphomas, diffuse large B-cell lymphomas, Burkitt’s lymphomas, and nodular lymphocyte predominant Hodgkin’s disease.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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