Thermo Fisher Scientific HHV-1 TK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
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Product Specifications

Target Information

Thymidine kinase catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. This enzyme allows the virus to reactivate and replicate in non-proliferative cells lacking phosphorylated nucleic acid precursors. It also phosphorylates and activates antiviral drugs such as acyclovir (ACV), valacyclovir, and famciclovir into toxic forms that suppress infection, while uninfected cells lacking TK remain unaffected. Mutations in thymidine kinase can lead to HSV resistance to antiviral therapies, particularly in immunocompromised patients. Resistant strains often lack TK expression and are avirulent in animal models, though some variants retain normal function but lose substrate recognition for ACV.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.