Thermo Fisher Scientific TMEM119 (extracellular) Polyclonal Antibody, FITC

Applications

Flow Cytometry (Flow)

• Tested Dilution: 2.5 µg

Product Specifications

Product Specific Information

• Reconstitution: 50 µL double distilled water (DDW), depending on sample size.
• The antibody ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution: store at 4°C (protected from light) for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Tmem119 encodes a single-pass type I transmembrane protein that interacts with various micro-RNAs and transcription factors such as SMAD1, SMAD5, and RUNX2.
It serves as a reliable surface marker for microglia, distinguishing them from infiltrating macrophages.
Microglial cells are brain-resident phagocytes involved in debris clearance and neuronal dendrite pruning, exhibiting both neuroprotective and neurotoxic roles depending on environmental cues.
Reactive microglia co-express Iba1 and are implicated in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Multiple Sclerosis.
Outside the nervous system, TMEM119 may play a role in osteoblast differentiation and ossification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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