Thermo Fisher Scientific TMEM119 (extracellular) Polyclonal Antibody, APC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 2.5 µg

Product Specifications

Product Specific Information

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Tmem119 encodes a single-pass type I transmembrane protein that interacts with multiple micro-RNAs and transcription factors such as SMAD1, SMAD5, and RUNX2.
It serves as a surface marker for microglia, distinguishing them from infiltrating macrophages. Microglia are brain-resident phagocytes involved in debris clearance and dendritic pruning, exhibiting neuroprotective and neurotoxic roles depending on their environment.
Reactive microglia co-express Iba1 and can induce A1-type astrocytes via secretion of Cq1, IL-1α, and TNF upon LPS stimulation, contributing to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s disease, and Multiple Sclerosis.
Outside the nervous system, Tmem119 is implicated in osteoblast differentiation and ossification.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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