Thermo Fisher Scientific SR-BI Polyclonal Antibody
SR-BI 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합. HDL 대사 연구 및 콜레스테롤 운반 기전 분석에 활용 가능. 액상 형태로 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution / Concentration |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 2.5–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 |
| Flow Cytometry (Flow) | 1:400 |
| Immunoprecipitation (IP) | 1:10–1:500 |
| Neutralization (Neu) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-terminal peptide corresponding to mouse SR-BI (aa 450–509) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2182826 |
Product Specific Information
Store as a concentrated solution. Centrifuge briefly prior to opening vial.
Target Information
High-density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk for atherosclerosis.
SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. It is expressed primarily in liver and nonplacental steroidogenic tissues and mediates selective cholesterol uptake through a distinct mechanism.
In mice, SR-BI plays a key role in determining plasma lipoprotein cholesterol levels and cholesterol storage in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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