Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI1F2), TrueMAB
COMMD1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC, Flow Cytometry에 사용 가능. 인간, 마우스, 랫트, 개에 반응하며, 액상 형태로 제공. NF-κB 조절 및 구리 항상성 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F2 |
| Immunogen | Full length human recombinant protein of human COMMD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Proposed scaffold protein implicated in various physiological processes, partly through regulation of ubiquitination of specific cellular proteins. It modulates cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promoting CRL E3 activity and dissociating CAND1 from CUL1 and CUL2. COMMD1 promotes ubiquitination and proteasomal degradation of NF-κB subunit RELA, leading to down-regulation of NF-κB activity.
It also regulates membrane expression and ubiquitination of SLC12A2, modulates Na⁺ transport via ENaC subunit ubiquitination, and promotes CFTR surface expression. Additionally, COMMD1 influences copper ion homeostasis and ATP7A trafficking, likely through its role in the CCC complex and cooperation with the WASH complex on early endosomes. It can bind one copper ion per monomer and may facilitate biliary copper excretion within hepatocytes. Furthermore, it interacts with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and regulates HIF1A-mediated transcription by competing with ARNT/Hif-1-beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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