Thermo Fisher Scientific CD27 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for regulating cell proliferation and death.
Expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 depend on proper antigen receptor ligation, while CD70 expression requires additional co-stimulatory or pro-inflammatory signals.
CD27 exists as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. Activation of T cells via the TCR-CD3 complex upregulates CD27 expression and leads to the release of a soluble 28–32 kDa form (sCD27), found in plasma, urine, or spinal fluid.
Soluble CD27 serves as an important prognostic marker for acute and chronic B cell malignancies. RgpA, a cysteine proteinase, can degrade CD27 and inhibit T cell activation mediated by CD27/CD70 interaction. The CD27-binding protein SIVA, a proapoptotic molecule, is thought to play a role in CD27-induced apoptosis.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.