Thermo Fisher Scientific Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9), FITC
FITC 형광 표지된 재조합 Rabbit Monoclonal 항체로, 인산화된 Chk1 (Ser345)을 특이적으로 검출합니다. 인간 및 생쥐 시료에 반응하며 Flow Cytometry에 적합합니다. Protein A/G로 정제되어 안정적이며, PBS/BSA 버퍼에 보관됩니다.
- 카탈로그번호
- MA537295
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S345-R3F9 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897229 |
Additional Formats
- Unconjugated (MA5-37019)
- APC (MA5-37022)
- PE (MA5-37020)
- Request custom conjugation (Thermo Fisher form)
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. This evolutionarily conserved kinase ensures genomic integrity upon genotoxic stress. When CHK1 inhibition abrogates the G2 or S checkpoint, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, whereas normal cells arrest in G1. Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer therapy, particularly in p53-deficient tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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