Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Nurr1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. WB, IHC, ICC 등 다양한 응용에 적합하며 인간 및 마우스 반응성. 고순도 정제 및 안정적인 액상 형태로 제공되어 신경계 연구에 활용 가능.
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- PA513416
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Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 13–42 amino acids from the N-terminal region of human NURR1 (NR4A2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.0 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2153896 |
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans. NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene are associated with dopaminergic dysfunction-related disorders such as Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, with additional alternate splice variants potentially existing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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