Thermo Fisher Scientific Phospho-Cdc37 (Ser13) Polyclonal Antibody
Phospho-Cdc37 (Ser13) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 세포주기 조절 단백질 CDC37의 인산화 상태 연구에 활용되며, HSP90 및 다양한 키나아제 복합체 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CDC37 around the phosphorylation site of Ser13 (E-V-SP-D-D) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555195 |
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs). It is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase. HSP90 has been shown to associate with many of the same targets as Cdc37. Cdc37 (also known as p50) forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src. It functions as a chaperone independently and cooperatively with HSP90, and is required for HSP90 binding to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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