Thermo Fisher Scientific Pancreatic Islet Lysate Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Pig

Host/Isotype

Dog

Class

Polyclonal

Type

Antibody

Immunogen

Sonicated crude membrane fraction of porcine pancreatic islets of langerhans cells if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PPY,uniProtId:P01300-1,ncbiNodeId:9821,antigenRange:1-65,antigenLength:65,antigenImageFileName:214-A01-118_PPY_P01300-1_Dog.svg,antigenImageFileNamePDP:214-A01-118_PPY_P01300-1_Dog_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Ion-exchange chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Dog Serum. Cross reactivity was determined by immunoblot (western) to be minimal against porcine kidney and porcine liver cell lysates.

Target Information

Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide with sequence and 3-D structural homology with NPY and PYY. PP is the least conserved of the three peptides and was the first to be identified. It is almost exclusively expressed in the endocrine pancreas and released in response to cholinergic stimulation and food intake. PP has inhibitory effects on gall bladder secretion, intestinal motility and pancreatic secretion. PP may serve as a marker for certain gut endocrine tumors including carcinoid tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.