Thermo Fisher Scientific DRG1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 158-367 of human DRG1 (NP_004138.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DRG1,uniProtId:Q9Y295-1,ncbiNodeId:9606,antigenRange:158-367,antigenLength:367,antigenImageFileName:PA5-120877_DRG1_Q9Y295-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120877_DRG1_Q9Y295-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.86 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914449

Product Specific Information

Positive test controls include: HepG2, A-549, 22Rv1, HT-29, Mouse liver, Mouse kidney, Rat liver. The target is usually found in the following locations: Cytoplasm.

Immunogen sequence: KKIIENELEG FGIRLNSKPP NIGFKKKDKG GINLTATCPQ SELDAETVKS ILAEYKIHNA DVTLRSDATA DDLIDVVEGN RVYIPCIYVL NKIDQISIEE LDIIYKVPHC VPISAHHRWN FDDLLEKIWD YLKLVRIYTK PKGQLPDYTS PVVLPYSRTT VEDFCMKIHK NLIKEFKYAL VWGLSVKHNP QKVGKDHTLE DEDVIQIVKK

Target Information

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of Lys-22 by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). [UniProt]

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.