Thermo Fisher Scientific GPR17 Polyclonal Antibody
GPR17 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 고순도 Affinity Chromatography로 정제되었습니다. 뇌 조직 등에서의 발현 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–94 of human GPR17 (NP_005282.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914446 |
Product Specific Information
- Positive test controls: Mouse spinal cord, Mouse brain, Rat brain
- Immunogen sequence:
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPA
Target Information
The G-protein-coupled receptor (GPCR) superfamily includes approximately 600–1,000 members and represents the largest class of molecular targets with therapeutic relevance.
GPR17 is an orphan GPCR involved in the regulation of oligodendrocyte differentiation and myelination in the central nervous system.
It is expressed in brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 shows dual specificity for uracil nucleotides and cysteinyl leukotrienes, signaling through G(i) and inhibiting adenylyl cyclase.
It may mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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