Thermo Fisher Scientific KLRB1 Monoclonal Antibody (10-78), Biotin
Rat NK 세포 표지자 NKR-P1(KLRB1)을 인식하는 단클론성 항체로, Biotin으로 표지됨. Flow Cytometry 및 IHC(F) 실험에 적합. 높은 특이성과 안정적인 성능 제공. Protein G로 정제되어 높은 순도 유지.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Assay-dependent
Flow Cytometry (Flow)
- 0.5 µg/1x10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10-78 |
| Immunogen | 60 kDa disulfide linked homodimer NKR-P1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538927 |
Additional Formats
Product Specific Information
MA5-17537 targets NK cells/NKR-P1 in FACS and IHC(F) applications and shows reactivity with Rat samples.
The MA5-17537 immunogen is a 60 kDa disulfide linked homodimer NKR-P1.
Target Information
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD161) is a type II membrane protein with an external C terminus.
It is expressed by nearly all NK cells and a subset of CD3+ T cells. KLRB1 forms a homodimeric cell surface protein (40–44 kDa) and plays an inhibitory role on NK cells.
Activation of KLRB1 induces acid sphingomyelnase/SMPD1 stimulation, increases intracellular ceramide, and activates AKT1/PKB and RPS6KA1/RSK1 kinases, enhancing T cell proliferation by anti-CD3.
KLRB1 acts as a lectin binding to Gal-alpha(1,3)Gal and N-acetyllactosamine epitopes, and also binds CLEC2D/LLT1 ligand, inhibiting NK cell-mediated cytotoxicity and interferon-gamma secretion.
It contains extracellular C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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