Thermo Fisher Scientific RARS Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000
• Publications: [References available]

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate
• Publications: [References available]

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases.
ArgRS (Arginyl-tRNA synthetase), also known as RARS or DALRD1, belongs to the class-I aminoacyl-tRNA synthetase family that includes LeuRS, ValRS, and IleRS.
These proteins are large monomeric enzymes that catalyze the aminoacylation of tRNA by their cognate amino acid. ArgRS localizes to the cytoplasm and exists as a monomer but can associate with other tRNA synthetases and auxiliary proteins to form a multisubunit complex.
In the presence of ATP, arginine (Arg), and tRNA, ArgRS joins Arg to tRNA(Arg) at its synthetic active site. Two cytoplasmic forms of ArgRS have been described in mammals, differing by the addition of a 73 amino acid sequence required for ArgRS assembly into the multisubunit complex.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.