Thermo Fisher Scientific NBS1 Recombinant Rabbit Monoclonal Antibody (9H4L65)
Western blot과 면역세포염색에 적합한 NBS1 항체. Expi293 시스템에서 발현된 재조합 토끼 단클론 항체로 높은 특이성과 일관된 품질을 제공. Monkey, Bovine, Horse, Sheep과 교차 반응 예측. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H4L65 |
| Immunogen | Protein corresponding to human NBS1 (aa400–aa754) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2716884 |
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Horse, and Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to the extensive rabbit immune repertoire
Target Information
The p95 gene (identical to NBS1 and nibrin) is part of the hMre11/hRad50 double-strand break complex. This complex is implicated in Nijmegen breakage syndrome, an autosomal recessive disorder characterized by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity. This highlights a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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