Thermo Fisher Scientific LGI1 Polyclonal Antibody
LGI1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC에 사용 가능. 사람, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 연구용으로만 사용.
- 카탈로그번호
- OSL00022W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 300–350 of mouse LGI1 conjugated to blue carrier protein. The peptide is homologous in rat and human. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: LGI1.
Target Information
The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers.
LGI1 belongs to a family of proteins containing leucine-rich repeats (LRRs), similar to transmembrane signaling molecules and receptors.
It serves as a ligand to ADAM22, a metalloprotease localized at the synapse.
Mutations in LGI1 are associated with autosomal dominant lateral temporal epilepsy (ADTLE), characterized by focal seizures with auditory symptoms.
Two isoforms of LGI1 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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