Thermo Fisher Scientific ZP2 Polyclonal Antibody
ZP2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 인간 시료에 반응하며, Protein A로 정제된 액상 항체입니다. PBS(2% sucrose) 버퍼에 보관되며, -20°C에서 냉동 보관이 권장됩니다.
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Applications
- Western Blot (WB): Tested at 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human ZP2 (aa 553–602) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608105 |
Product Specific Information
Peptide sequence:
PDSFPQWNVV VDGCAYDLDN YQTTFHPVGS SVTHPDHYQR FDMKAFAFVS
Sequence homology:
- Cow: 79%
- Dog: 86%
- Guinea Pig: 86%
- Horse: 79%
- Human: 100%
- Rabbit: 93%
- Rat: 86%
Target Information
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development.
The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa.
The nascent protein contains an N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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