Thermo Fisher Scientific ROR-gamma/RORC (RAR-related Orphan Receptor C) Monoclonal Antibody (RORC/2941)
RORC/2941 단클론 항체로 인간 ROR-γ 단백질을 특이적으로 인식. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. PBS 버퍼 내 액상 형태로 제공되며, 단백질 A/G로 정제됨. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RORC/2941 |
| Immunogen | Recombinant full-length human RORC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ROR gamma is a 560-amino-acid DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest that ROR gamma is a ligand-activated transcription factor essential for lymphoid organogenesis (lymph nodes and Peyer’s patches) and plays a regulatory role in controlling apoptosis during thymopoiesis. It inhibits the expression of Fas ligand and IL2 and directs the differentiation of proinflammatory IL-17+ T helper cells. ROR gamma shares 50–51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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