Thermo Fisher Scientific PSME4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.

Target Information

PSME4 is an associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and the DNA damage response.
It binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry.
PSME4 interacts with the core proteasome via its C-terminus, occupying the same binding sites as proteasomal ATPases and promoting an active gating mechanism.
It is a component of the spermatoproteasome, a testis-specific form of the proteasome that facilitates histone exchange during spermatogenesis, and also functions in somatic cells during DNA damage response by promoting histone degradation following double-strand breaks.
[Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.