Thermo Fisher Scientific PSME4 Polyclonal Antibody
Rabbit polyclonal antibody against human PSME4, suitable for WB, IHC, and IP applications. Recognizes residues 1–50 of PSME4. Supplied as liquid, 1 mg/mL, stored at 4 °C. Recommended for proteasome and histone degradation research.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Proteasome (Prosome, Macropain) Activator subunit 4 (PSME4, UniProt ID: Q14997-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
PSME4 is an associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and the DNA damage response.
It binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry.
PSME4 interacts with the core proteasome via its C-terminus, occupying the same binding sites as proteasomal ATPases and promoting an active gating mechanism.
It is a component of the spermatoproteasome, a testis-specific form of the proteasome that facilitates histone exchange during spermatogenesis, and also functions in somatic cells during DNA damage response by promoting histone degradation following double-strand breaks.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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