Thermo Fisher Scientific Urokinase Monoclonal Antibody (1A2G4G11)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human uPA/PLAU.

Target Information

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer’s disease and decreased affinity for fibrin-binding.
This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative (HMW-uPA). HMW-uPA can be further processed into LMW-uPA, which remains proteolytically active but does not bind to the uPA receptor.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.