Thermo Fisher Scientific CD14 Monoclonal Antibody (31G4)
Rabbit monoclonal antibody (clone 31G4) specific to human CD14, suitable for WB, IHC(P), and ICC/IF. Unconjugated, liquid form at 1 mg/mL concentration. Stored at -20°C and shipped on wet ice for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 31G4 |
| Immunogen | Human CD14 between amino acids 20–350 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein expressed on mature monocytes, macrophages, and neutrophils. It functions as a multifunctional lipopolysaccharide receptor and exists in both membrane-bound and soluble forms. CD14 binds lipopolysaccharides via LBP and plays a role in immune response modulation, including recognition of apoptotic cells and participation in allergic, inflammatory, and infectious processes. Alternative splicing generates multiple transcript variants encoding the same CD14 isoform. CD14 dysfunction is associated with diseases such as Mycobacterium chelonae infection and croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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