Thermo Fisher Scientific PDZ-RhoGEF Polyclonal Antibody
PDZ-RhoGEF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 IHC(Paraffin) 실험에 사용 가능하며, Human에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로 4°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1472 and 1522 of human PDZ-RhoGEF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Gorilla and Chimpanzee
Target Information
ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline-rich sequences, and a regulatory G protein-signaling (RGS) sequence.
It acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42, and as a GTPase-activating protein (GAP) for GNA12 and GNA13.
Forms a complex with G proteins and stimulates neurite retraction through Rho-dependent signals.
ARHGEF11 increases glutamate transport fourfold, interacts with EAAT4, and modulates uptake activity and perisynaptic distribution at glutamatergic synapses.
It induces actin cytoskeleton reorganization, membrane ruffling, and filopodia formation.
Ubiquitously expressed in brain, lung, liver, kidney, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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