Thermo Fisher Scientific CD178 (Fas Ligand) Monoclonal Antibody (MFL3), FITC, eBioscience
Mouse Fas Ligand(CD178) 검출용 FITC 결합 단클론 항체로, Flow Cytometry에 최적화됨. Armenian hamster IgG 기반으로 높은 특이성과 재현성을 제공. 488 nm excitation, 520 nm emission 특성. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD178 (Fas Ligand) Monoclonal Antibody (MFL3), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 2 publications |
| Flow Cytometry (Flow) | 1 µg/test | View 9 publications |
Product Specifications
| Parameter | Description |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MFL3 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11149348 |
Available Formats
- APC
- APC-eFluor 780
- Biotin
- Functional Grade
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation available
Product Specific Information
The MFL3 monoclonal antibody reacts with mouse Fas (CD95) Ligand, a 40 kDa type II transmembrane glycoprotein. FasL is a TNF family member expressed by activated T cells. Interaction with its receptor CD95 induces Fas-mediated apoptosis. Human FasL can be cleaved by MMPs to form a 26 kDa soluble form; sensitivity of mouse FasL to MMPs is not reported.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse CD178 transfected cell line; ≤1 µg/test (100 µL final volume). Optimal titration recommended.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD178 (Fas ligand, FasL) is a type-II membrane protein with an N-terminal cytoplasmic domain and a C-terminal extracellular domain. Its receptor, FasR, is a type-I membrane protein in the TNF/NGF receptor family. CD178 induces apoptosis upon FasR interaction and exists in both membrane-bound (45 kDa) and soluble (26 kDa) forms. The soluble form arises from metalloproteinase cleavage.
CD178 is expressed in activated T-lymphocytes, NK cells, and immune-privileged tissues (testis, eye). Expression also occurs in thymus, liver, ovary, lung, heart, and kidney. CD178-mediated apoptosis plays a key role in antiviral immune responses and immune regulation. Altered CD178 levels are associated with inflammatory diseases and atherosclerosis. The Fas/CD178 system is implicated in AIDS, hepatitis, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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