Thermo Fisher Scientific NEK4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total NEK4.

Target Information

NEK4 is a serine/threonine kinase involved in signal transduction and cellular communication. It acts primarily on threonine residues and is expressed in most primary carcinomas. Protein kinases catalyze the transfer of phosphate groups from ATP to specific amino acids in substrate proteins, mediating key cellular processes such as metabolism, transcription, cell cycle progression, cytoskeletal organization, apoptosis, and differentiation.

The protein kinase family, comprising over 500 gene products, is classified into eight major groups based on sequence similarity of catalytic domains. The STE group includes kinases related to the MAPK cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and upstream kinases (MAPKKs), are well characterized in yeast pheromone response pathways, where pheromones activate surface receptors and trigger the MAPK pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.