Thermo Fisher Scientific SMAD9 Monoclonal Antibody (3E5)
SMAD9 단백질을 표적하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 3E5). Western blot 및 ELISA에 적합하며 인간 시료에 반응. 액상형, PBS buffer, 무보존제. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E5 |
| Immunogen | Full length recombinant SMAD9 (NP_005896, 146 a.a. approximately 260 a.a) with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of SMAD9 protein:
RHSEYNPQLS LLAKFRSASL HSEPLMPHNA TYPDSFQQPP CSALPPSPSH AFSQSPCTAS YPHSPGSPSE PESPYQHSDF RPVCYEEPQH WCSVAYYELN NRVGETFQAS SRSVL
Target Information
SMADs are members of the MAD-related family of intracellular proteins essential in the signaling pathways of serine/threonine kinase receptors of the transforming growth factor beta (TGF-β) superfamily.
SMADs are categorized as:
- Receptor-regulated SMADs (R-SMADs): SMAD1, 2, 5, 8, and 9
- Common-mediator SMAD (co-SMAD): SMAD4
- Inhibitory SMADs (I-SMADs): SMAD6 and 7
SMAD1, 5, 8, and 9 share high homology, and antibodies often recognize common sequences. SMAD8 and SMAD9 are used interchangeably in literature. Mutations in SMAD9 can lead to pulmonary hypertension, primary 2 (PPH2).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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