Thermo Fisher Scientific Complement C9 Polyclonal Antibody
Thermo Fisher Scientific의 Complement C9 Polyclonal Antibody는 인간 C9 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 153–429 of Human C9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546542 |
Product Specific Information
- Recommended positive control: Jurkat cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b, which initiates assembly of the C5b-9 complex. The final step of C5b-9 formation involves polymerization of C9, enabling insertion of the complex into the cell membrane.
During formation of C5b-8 and C9 polymerization, neoantigens unique to the C5b-9 complex are generated. Complement regulatory proteins CD59 and complement S-protein can prevent C5b-9 membrane insertion. The SC5b-9 complex, unable to attach to cells, is cytolytically inactive.
C5b-9 is implicated in chronic proteinuric renal disease progression by mediating continuous tubulointerstitial damage. Early injury can be mitigated when C5b-9 complex formation is inhibited.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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