Thermo Fisher Scientific OX40L Polyclonal Antibody
Human TNFSF4(OX40L)에 특이적인 Rabbit Polyclonal Antibody로, Western Blot에 적합. Affinity Chromatography로 정제된 액상 제품이며, PBS와 sucrose buffer에 보존. 항원제시세포 및 T세포 활성 연구용으로 사용 가능.
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Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human TNFSF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609149 |
Product Specific Information
- Peptide sequence: QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL
- Sequence homology: Human: 100%
Target Information
The tumor necrosis factor superfamily member TNFSF4 (OX40L) is a type II membrane-bound, non-covalently linked homotrimeric protein. It is expressed on antigen-presenting cells such as dendritic cells and activated B-cells, as well as on vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals through the TNFRSF4 receptor, which is expressed predominantly on CD4+ T cells and certain activated CD8+ T cells. The TNFRSF4/TNFSF4 interaction provides a costimulatory signal essential for effective communication between antigen-presenting cells and T cells, enhancing cell proliferation, survival, and cytokine expression (RANTES, IL-2, IL-3, IFN-γ). This signaling pathway plays a key role in immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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