Thermo Fisher Scientific Cyclin C Polyclonal Antibody
Cyclin C 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간 Cyclin C의 233–283 영역을 면역원으로 제작되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 4°C에서 보관하며, FFPE 조직은 citrate 또는 Tris-EDTA buffer로 epitope retrieval 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 233 and 283 of human Cyclin C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 9.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Chicken, and Bovine.
Target Information
Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knockout of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with CDK8, a novel protein kinase of the CDK family. It is suggested that Cyclin C and CDK8 control RNA polymerase II function. Human CDK8–Cyclin C complex might be functionally associated with the mammalian transcription apparatus, possibly involved in relaying growth regulatory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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