Thermo Fisher Scientific PCBP2 Polyclonal Antibody
PCBP2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol 완충액에 보관됩니다.
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- PA576661
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human PCBP2 (amino acids 1–365) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at –20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720388 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The PCBP2 protein is a multifunctional poly(rC)-binding protein, along with PCBP-1 and hnRNPK. It contains three K-homologous (KH) domains involved in RNA binding.
Together with PCBP-1, it acts as a translational coactivator of poliovirus RNA by interacting with the IRES region, promoting RNA replication.
PCBP2 is also implicated in the translational regulation of 15-lipoxygenase mRNA, HPV type 16 L2 mRNA, and hepatitis A virus RNA.
Additionally, it contributes to the stability of alpha-globin mRNA through formation of a specific mRNP complex.
This gene has paralogs (PCBP3, PCBP4) and processed pseudogenes (PCBP2P1, PCBP2P2), with multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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