Thermo Fisher Scientific HIP1 Polyclonal Antibody
HIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HIP1. Recombinant protein control fragment (Product #RP-90751). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642440 |
Product Specific Information
Immunogen sequence:
NFLRASALSE HISPVVVIPA EASSPDSEPV LEKDDLMDMD ASQQNLFDNK FDDIFGSSFS SDPFNFNSQN GVNKDEKDHL IERLYREISG LKAQLENMKT ESQRVVLQLK GHVSELEADL AEQQHLRQQA ADDCEFLRAE LDELRRQRED
Highest antigen sequence identity to the following orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. HIP-1 also plays a role in recruiting clathrin coats to lipid membranes and may contribute to tumorigenesis by promoting survival of precancerous and cancerous cells. HIP-1 expression is significantly associated with prostate and colon cancer metastasis, making it a potential prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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