Thermo Fisher Scientific Cathepsin C Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MLEARIRILTN NSQTPILSPQ EVVSCSQYAQ GCEGGFPYLI AGKYAQDFGL VEEACFPYTG TDSPCKMKED CFRYYSS

Highest antigen sequence identity to the following orthologs:

• Mouse: 87%
• Rat: 88%

Target Information

Cathepsin C, also known as dipeptidyl aminopeptidase I (DPPI), is a tetrameric lysosomal cysteine peptidase of the papain family. It is involved in intracellular protein degradation and processing of protein precursors, contributing to cell growth, neuraminidase activation, and platelet factor XIII activation.
Cathepsin C is related to other lysosomal cysteine proteinases such as cathepsin B, H, and L. It sequentially removes dipeptides from the amino terminus and requires halide ions (chloride) and thiols for full enzymatic activity.
Protein expression is highest in spleen, kidney, cytotoxic lymphocytes, and myeloid cells, where it localizes to secretory granule compartments. Synthesized initially as a proenzyme, Cathepsin C is processed into two distinct chains forming the mature enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.