Thermo Fisher Scientific PCBP1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Immunogen sequence: ICAGGQDRCSD AAGYPHATHD LEGPPL
• Antigen sequence identity: Mouse 100%, Rat 56%

Target Information

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It, along with PCBP-2 and hnRNPK, corresponds to the major cellular polydomains which may be involved in RNA binding.

This encoded protein, together with PCBP-2, also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.