Thermo Fisher Scientific PABPN1 Polyclonal Antibody
PABPN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. Human 및 Mouse 반응성 검증. 고순도 항원 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
- 카탈로그번호
- PA527433
- 판매단위
- pk
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Thermo Fisher Scientific PABPN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 124–306 of Human PABPN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.49 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544909 |
Product Specific Information
- Recommended positive controls: Jurkat, Raji, mouse brain
- Predicted reactivity: Mouse (98%), Rat (99%), Zebrafish (82%), Xenopus laevis (88%), Dog (100%), Pig (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3′ ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt.
At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm.
This gene contains a GCG trinucleotide repeat at the 5′ end of the coding region, and expansion of this repeat (from the normal 6 copies to 8–13 copies) leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD). Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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