Thermo Fisher Scientific TRIM25 Polyclonal Antibody
TRIM25 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합. 인간 단백질에 반응하며 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
- Publications: References
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 75 and 125 of Human tripartite motif-containing 25 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
TRIM25, also known as estrogen responsive finger protein (EFP), is a member of the RING finger-B box-coiled coil family and a downstream target of estrogen receptor α.
Mice lacking this gene show underdeveloped uterus and reduced estrogen responsiveness, demonstrating its essential role in estrogen-dependent proliferation.
TRIM25 expression increases in breast carcinoma, promoting tumor growth by functioning as an E3 ubiquitin ligase targeting the negative cell cycle checkpoint protein 14-3-3σ.
Recent studies indicate that TRIM25 E3 ubiquitin ligase is critical for the RIG-I signaling pathway, mediating host antiviral innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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