Thermo Fisher Scientific TIMP4 Polyclonal Antibody
TIMP4 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적. 연구용으로 MMP 억제 관련 연구에 적합.
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Thermo Fisher Scientific TIMP4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 30–224 of human TIMP4 (NP_0032471) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806560 |
Product Specific Information
Immunogen sequence:
CSCAPAHPQQ HICHSALVIR AKISSEKVVP ASADPADTEK MLRYEIKQIK MFKGFEKVKD VQYIYTPFDS SLCGVKLEAN SQKQYLLTGQ VLSDGKVFIH LCNYIEPWED LSLVQRESLN HHYHLNCGCQ ITTCYTVPCT ISAPNECLWT DWLLERKLYG YQAQHYVCMK HVDGTCSWYR GHLPLRKEFV DIVQP
Positive Samples:
HT-29, Mouse heart, Mouse brain, Mouse ovary, Rat heart, Rat brain
Target Information
Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. It belongs to the family of TIMP genes and inhibits matrix metalloproteinases (MMPs), which degrade extracellular matrix components. TIMP4 irreversibly binds to MMPs and inactivates them with zinc as a cofactor. The netrin domain of TIMP4 is involved in platelet recruitment and aggregation. Other biological roles include response to cytokine and peptide hormone stimuli, and involvement in ovulation cycle and CNS development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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