
Thermo Fisher Scientific TIMP4 Polyclonal Antibody
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:500-1:2,000
View 1 publication 1 publication
Immunocytochemistry (ICC/IF)
1:50-1:200
ELISA (ELISA)
1 µg/mL
Product Specifications
Species Reactivity
Human, Mouse, Rat
Published species
Not Applicable
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 30-224 of human TIMP4 (NP_0032471) if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
TIMP4,
uniProtId:
Q99727-1,
ncbiNodeId:
9606,
antigenRange:
30-224,
antigenLength:
224,
antigenImageFileName:
PA5-92959_TIMP4_Q99727-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-92959_TIMP4_Q99727-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1.48 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806560
Product Specific Information
Immunogen sequence: CSCAPAHPQQ HICHSALVIR AKISSEKVVP ASADPADTEK MLRYEIKQIK MFKGFEKVKD VQYIYTPFDS SLCGVKLEAN SQKQYLLTGQ VLSDGKVFIH LCNYIEPWED LSLVQRESLN HHYHLNCGCQ ITTCYTVPCT ISAPNECLWT DWLLERKLYG YQAQHYVCMK HVDGTCSWYR GHLPLRKEFV DIVQP; Positive Samples: HT-29, Mouse heart, Mouse brain, Mouse ovary, Rat heart, Rat brain
Target Information
Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. It belongs to the family of TIMP genes and is known to inhibit the activity of matrix metalloproteinases. Matrix metalloproteinases (MMP) are a group of proteinases that degrade the components of extracellular matrix. TIMP4 irreversibly binds to MMPs and inactivates them with the help of zinc as a cofactor. The netrin domain of TIMP4 is involved in platelet recruitment and aggregation. Other biological functions include response to cytokine and peptide hormone stimuli and involvement with the ovulation cycle and CNS development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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