Thermo Fisher Scientific PCAF Monoclonal Antibody (4H8)
Thermo Fisher Scientific의 PCAF Monoclonal Antibody (4H8)은 인간 PCAF 단백질을 인식하는 Mouse IgG2b 항체로, Western blot 및 ELISA에 사용 가능. 비결합형 액상 형태로 제공되며, -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- H00008850-M15A
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H8 |
| Immunogen | PCAF (NP_003875, 367–432 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QDFLSASSRT SQLGIQTVIN PPPVAGTISY NSTSSSLEQP NAGSSSPACK ASSGLE
Target Information
PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles.
PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A.
Additionally, PCAF acts as a circadian transcriptional coactivator enhancing the activity of NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.
It is involved in heart and limb development by mediating acetylation of TBX5 and regulating nucleocytoplasmic shuttling of TBX5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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