Thermo Fisher Scientific alpha Synuclein Polyclonal Antibody
인간 alpha-Synuclein을 인식하는 Rabbit Polyclonal Antibody로 Western blot, ELISA, Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 용액 형태로 제공됩니다. 파킨슨병 및 알츠하이머 연구용으로 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA (ELISA)
- Tested Dilution: 1:5,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1–4 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SNCA / alpha-Synuclein protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2902869 |
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, which encodes alpha-synuclein, are implicated in the pathogenesis of Parkinson’s disease. Additionally, alpha-synuclein peptides are major components of amyloid plaques in the brains of Alzheimer’s disease patients. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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