Thermo Fisher Scientific RPS10 Polyclonal Antibody

Thermo Fisher Scientific RPS10 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
GVMVAKKDVH MPKHPELADK NVPNLHVMKA MQSLKSRGCV KEQF

Highest antigen sequence identity to the following orthologs:

• Mouse: 98%
• Rat: 98%

Target Information

Ribosomes, the organelles that catalyze protein synthesis, are composed of a small subunit (40S) and a large subunit (60S) that consist of over 80 distinct ribosomal proteins. Mammalian ribosomal proteins are encoded by multigene families that contain processed pseudogenes and one functional intron-containing gene within their coding regions.
Ribosomal Protein S10 (RPS10) is a 165 amino acid component of the small ribosomal 40S subunit. While generally found in the cytoplasm, RPS10 can localize to the granular component (GC) region of the nucleolus. For this to occur, methylation by PRMT5 is required as well as an interaction with NPS1.
Defects in RPS10 are the cause of Diamond-Blackfan anemia type 9 (DBA9), a congenital non-regenerative hypoplastic anemia that usually presents early in infancy and is characterized by moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.