Thermo Fisher Scientific RPS10 Polyclonal Antibody
Human RPS10 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 적용 가능. 고순도 항원 친화 크로마토그래피 정제. PBS/glycerol 버퍼에 보관하며 연구용으로 적합.
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Thermo Fisher Scientific RPS10 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RPS10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646770 |
Product Specific Information
Immunogen sequence:
GVMVAKKDVH MPKHPELADK NVPNLHVMKA MQSLKSRGCV KEQF
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
Ribosomes, the organelles that catalyze protein synthesis, are composed of a small subunit (40S) and a large subunit (60S) that consist of over 80 distinct ribosomal proteins. Mammalian ribosomal proteins are encoded by multigene families that contain processed pseudogenes and one functional intron-containing gene within their coding regions.
Ribosomal Protein S10 (RPS10) is a 165 amino acid component of the small ribosomal 40S subunit. While generally found in the cytoplasm, RPS10 can localize to the granular component (GC) region of the nucleolus. For this to occur, methylation by PRMT5 is required as well as an interaction with NPS1.
Defects in RPS10 are the cause of Diamond-Blackfan anemia type 9 (DBA9), a congenital non-regenerative hypoplastic anemia that usually presents early in infancy and is characterized by moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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