Thermo Fisher Scientific Pannexin 2 Polyclonal Antibody

Applications and Tested Dilution

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Target Information

Gap junctions are channel-forming structures that allow direct metabolic and electrical communication between adjacent cells in most mammalian tissues. They are absent only in adult skeletal muscle cells and certain circulating blood cells.
A gap junction consists of two hemichannels, each composed of six subunits. In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are found only in chordates, while pannexins are present in both chordate and invertebrate genomes.

Pannexins, previously known as innexins, are predicted to contain four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini. Both human and mouse genomes have three pannexin genes. Pannexin 2 (Px2, PANX2) is a brain-specific gene abundantly expressed in the central nervous system, similar to pannexin 1. In neuronal populations such as hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed, while in white matter only pannexin 1-positive cells are found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.