Thermo Fisher Scientific Laminin, gamma 1 (LAMC1) Monoclonal Antibody (LAMC1/3162)
LAMC1/3162 단클론 항체로 인간 및 생쥐 Laminin γ1 단백질을 특이적으로 인식. IHC 및 Peptide Array 등 다양한 응용에 적합. Protein A/G로 정제된 액상 형태로 제공되며, 안정적인 4°C 보관 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LAMC1/3162 |
| Immunogen | Murine EHS laminin preparation (Laminin gamma-1, UniProt ID: P02468-1, antigen length: 1607 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes are polymers of Laminins stabilized by Type IV Collagen networks, Nidogen, and proteoglycans. They are found beneath epithelial layers, around blood vessel endothelium, and surrounding muscle, peripheral nerve, and fat cells.
Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture.
Each Laminin is a heterotrimer of alpha, beta, and gamma chain subunits that undergoes secretion and incorporation into the extracellular matrix (ECM). Laminins can self-assemble, bind to other matrix macromolecules, and interact with cells via Integrins, dystroglycan, and Laminin receptors.
The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues producing basement membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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