Thermo Fisher Scientific NOX4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 328-578 of human NADPH oxidase 4 (NOX4) (NP_0586271) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NOX4,uniProtId:Q9NPH5-1,ncbiNodeId:9606,antigenRange:328-578,antigenLength:578,antigenImageFileName:PA5-88106_NOX4_Q9NPH5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88106_NOX4_Q9NPH5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.49 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804655

Product Specific Information

Positive Samples: U2OS; Cellular Location: Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus, focal adhesion, nucleolus

Immunogen sequence: KENFKARPGQ YITLHCPSVS ALENHPFTLT MCPTETKATF GVHLKIVGDW TERFRDLLLP PSSQDSEILP FIQSRNYPKL YIDGPFGSPF EESLNYEVSL CVAGGIGVTP FASILNTLLD DWKPYKLRRL YFIWVCRDIQ SFRWFADLLC MLHNKFWQEN RPDYVNIQLY LSQTDGIQKI IGEKYHALNS RLFIGRPRWK LLFDEIAKYN RGKTVGVFCC GPNSLSKTLH KLSNQNNSYG TRFEYNKESF S

Target Information

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.