Thermo Fisher Scientific NOX4 Polyclonal Antibody
Thermo Fisher Scientific의 NOX4 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 토끼 IgG 항체입니다. Western blot, IHC, ELISA에 적합하며 세포막 및 세포소기관 내 NOX4 단백질 검출에 사용됩니다. 액상 형태로 -20°C에서 보관합니다.
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- PA588106
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 328–578 of human NADPH oxidase 4 (NOX4) (NP_058627.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.49 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804655 |
Product Specific Information
- Positive Samples: U2OS
- Cellular Location: Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus, focal adhesion, nucleolus
Immunogen sequence:
KENFKARPGQ YITLHCPSVS ALENHPFTLT MCPTETKATF GVHLKIVGDW TERFRDLLLP PSSQDSEILP FIQSRNYPKL YIDGPFGSPF EESLNYEVSL CVAGGIGVTP FASILNTLLD DWKPYKLRRL YFIWVCRDIQ SFRWFADLLC MLHNKFWQEN RPDYVNIQLY LSQTDGIQKI IGEKYHALNS RLFIGRPRWK LLFDEIAKYN RGKTVGVFCC GPNSLSKTLH KLSNQNNSYG TRFEYNKESF S
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, has been postulated to function in the kidney as an oxygen sensor regulating erythropoietin synthesis in the renal cortex.
NOX4 acts as a redox messenger in intracellular signaling pathways contributing to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest NOX4 links the insulin receptor to ROS generation, enhancing insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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